| Message: | 4-Androstenedione, popularly known as Androstenedione or 4-AD, has many other names. The synonyms of 4-Androstenedione include 17-ketoestosterone, Andro, Androstene,Androst-4-ene-3,17-dione,4-Androstene-3,17-dione, 4-Androstenedione, Androtex, 63-05-8, 3,17-Dioxoandrost-4-ene, Fecundin,
4-AD,SKF 2170 etc. If you are not sure whether it is 4-Androstenedione, make sure that there is only one CAS number for it, and it is 63-05-8.
According to Wikipedia, 4-Androstenedione is a 19-carbon steroid hormone produced in the adrenal glands and the gonads as an intermediate step in the biochemical pathway that produces the androgen testosterone and the oestrogens oestrone and oestradiol. 4-Androstenedione originates either from the conversion of dehydroepiandrosterone (DHEA) or from 17- hydroxyprogesterone. Conversion of dehydroepiandrosterone to androstenedione requires 3-ß-hydroxysteroid dehydrogenase. 17- hydroxyprogesterone, on the other hand, requires 17, 20 lyase for its synthesis. Thus, both reactions that produce androstenedione directly or indirectly depend on 17, 20 lyase. 4-Androstenedione is further converted to either testosterone or oestrogen. Conversion of 4-androstenedione to testosterone requires the enzyme 17ßhydroxysteroid dehydrogenase, while conversion of androstenedione to oestrogen (e.g. oestrone and oestradiol) requires the enzyme aromatase. The production of adrenal androstenedione is governed by ACTH(Adrenocorticotropic Hormone), whereas production of gonadal androstenedione is under control by gonadotropins. In premenopausal women, the adrenal glands and ovaries each produce about half of the total androstendione .
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