| Message: | 4-androstenediol, also known as androst-4-ene-3β, 17β-diol, is an androstenediol converted to testosterone. Due to the different enzyme pathways, the conversion is about 15.76%, almost three times that of 4-androstenedione. Still others are converted to estrogen because testosterone is a metabolic precursor of estrogen.
4-androstene diol is closer to testosterone than structural 5-androstene diol and has the effect of androgen, the androgen receptor as a weak partial agonist. [1] However, due to its lower intrinsic activity, in the presence of a full agonist such as testosterone or dihydrotestosterone (DHT), 4-androstenediol has an antagonistic effect and behaves more like an antiandrogen.
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