| Message: | Estradiol (17β-estradiol) is a sex hormone. It represents the main estrogen of humans. Estradiol not only has an important effect on reproduction and sexual function, but also affects other organs, including bone structure.
In the reproductive years, most of the female estradiol is produced by the ovaries, and a small amount of estradiol is also produced by the adrenal cortex. In men, the testes produce estradiol.
In plasma, estradiol binds primarily to sex hormone binding globulin (SHBG) and also to albumin, with only a portion having free and biological activity.
Female serum estradiol measurements primarily reflect ovarian activity. During pregnancy, estrogen levels, including estradiol, steadily rise to full term. Estradiol increases due to placenta production.
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