| Message: | Application:AICAR is being clinically used to treat and protect against cardiac ischemic injury. If left untreated, it may lead to a myocardial infarct. Cardiac Ischemia is caused by insufficient blood flow and oxygen to the myocardium .The drug was first used in the 1980’s as a method to preserve blood flow to the heart during surgery. Currently,the drug has also been shown as a potential treatment for diabetes by increasing the metabolic activity of tissues by changing the physical composition of muscle. (1) Applied in phamaceutical field, it is used as phamaceutical raw material to treat injuries from fall, infectious hepatitis and epidemic cerebrospinal meningitis. (2) Applied in healthcare field, it is used in the health products to nourish brain, protect liver and improve sleep quality. (3) Applied in comestics, it is used to promote skin metabolism and make skin more tender and firm. Product descrition:AICAR is a cell permeable activator of AMP-activated protein kinase(AMPK),a metabolic master regulator that is activated in times of reduced energyavailability(high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulins-independent glucose uptake by skeletal muscle. Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCsin vitro. Biological Activity:Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. url:http://www.kangrui-biotech.com |
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