| Message: | 99% Flumazenil For Treating Benzodiazepine Overdoses CAS: 78755-81-4
1. Quick detail:
Product Name Flumazenil
Alias Flumazepil
CAS 78755-81-4
Purity 99.0%
Grade Pharmaceutical Grade
Brand Name NJBN STEROIDS
M.F. C15H14FN3O3
M.W. 303.29
Appearance White power
Storage Original package at cool dark place
2. Description:
Flumazenil (also known as flumazepil, code name Ro 15-1788) is a selective benzodiazepine receptor antagonist primarily available by injection only, and the only GABAA negative allosteric modulator on the market today. It has antagonistic and antidote properties to therapeutically used benzodiazapenes, through competitive inhibition.
It was first introduced in 1987 by Hoffmann-La Roche under the trade name Anexate, but only approved by the FDA on December 20, 1991. Flumazenil went off patent in 2008, so at present generic formulations of this drug are available. Intravenous flumazenil is primarily used to treat benzodiazepine overdoses and to help reverse anesthesia. Administration of flumazenil by sublingual lozenge and topical cream has also been tested.
3. Application:
Flumazenil is of benefit in patients who become excessively drowsy after benzodiazepines are used for either diagnosticor therapeutic procedures.
It has been used as an antidote in the treatment of benzodiazepine overdoses. It reverses the effects of benzodiazepines by competitive inhibition at the benzodiazepine binding site on the GABAA receptor. There are many complications that must be taken into consideration when used in the acute care setting. These include lowered seizure threshold, agitation, and anxiousness. Flumazenils short half-life requires multiple doses and careful patient monitoring to prevent recurrence of overdose symptoms.
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