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Norethisterone (Acetate)

Create: 05/04/2017
Expired Date:05/12/2017
Category: Chemical
Message:Norethisterone (Acetate) Megestrol Acetate CAS NO.: 595-33-5 EINECS: 209-864-5 Assay: 99% Molecular Formula:C24H32O4 Molecular Weight:384.51 Appearance: White or light yellow crystalline powder (methanol), odorless and tasteless. Melting point 214-216. Soluble in acetone, slightly soluble in ethanol, insoluble in water Product Description : Megestrol acetate (INN, USAN, BAN, JAN) (abbreviated as MGA or MA, and sold mainly under the brand names Megace and Megace ES), also known as 17α-acetoxy-6-dehydro-6-methylprogesterone, is a steroidal progestin and progesterone derivative (specifically, a 17-hydroxylated progesterone) with predominantly progestational and antigonadotropic effects. Though sometimes referred to simply as megestrol, it is important to clarify that megestrol acetate is not the same as megestrol, which is a closely related but different compound. Megestrol acetate has powerful antiandrogenic and antiestrogenic effects in humans at sufficient doses, capable of decreasing circulating androgen and estrogen concentrations to castrate levels in both sexes and significantly lowering the expression of the androgen receptor (AR) and the estrogen receptor (ER) in the body. Application : (1). Mainly used for short-acting oral contraceptives, also can be used for intramuscular injection of long-acting contraceptives. (2). For the treatment of dysmenorrhea, amenorrhea, dysfunctional uterine bleeding, endometriosis and endometrial adenocarcinoma.  
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