| Message: | Sildenafil Citrate Profile:
Vardenafil's indications and contra-indications are the same as with other PDE5 inhibitors; it is closely related in function to sildenafil citrate (Viagra) and tadalafil (Cialis). Sildenafil Citrate is solely active in relaxing muscles and increasing blood flow to the heart, lungs and penis due to PDE-5, yet vasodilation is not increased in other parts of the body.
Applications:
Sildenafil citrate, sold as Viagra, Revatio and under various other trade names, is a drug used to treat erectile dysfunction and pulmonary arterial hypertension (PAH).
tadalafil's pharmacologic distinction is its longer half-life (17.50 hours) - compared to sildenafil (4.0-5.0 hours) and vardenafil (4.0-5.0 hours) - resulting in longer duration of action, and so partly responsible for "The Weekend Pill" sobriquet. Furthermore, the longer half-life is the basis for current investigation of tadalafil's daily therapeutic use in relieving pulmonary arterial hypertension. Sildenafil is approved in several world regions as a thrice-daily therapy for pulmonary arterial hypertension.
Sildenafil citrate 50 mg is the recommended starting dose for men with erectile dysfunction (ED); however, most men are later titrated to sildenafil 100 mg for improved efficacy.
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