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Tibolone is a synthetic hormone-type drug which is used mainly for hormone replacement therapy in post-menopausal women. It is a synthetic steroid that has the same activity as the female sex hormones estrogen and progesterone and the androgen testosterone. Tibolone helps restore hormonal balance in the body.
When estrogen levels are low tissues can slowly degenerate, as is experienced during menopause. In addition, low levels of estrogen can cause distressing symptoms such as hot flushes, night sweats, mood swings, reduced sex drive and vaginal dryness. Tibolone is broken down into three compounds which act in a similar way to the natural estrogen and progesterone found in the body. It restores plasma endorphin level in post-menopausal women and acts centrally to affect the thermo-regulatory system.
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