| Message: | Amikacin disulfate salt has anti-infectives for the treatment of urinary tract infections caused by susceptible strains, septicemia, skin infections, bone and joint infections, pneumonia and lower respiratory tract infections
Amikacin, sold under the brandname Amikin, is an aminoglycoside antibiotic used to treat different types of bacterial infections. Amikacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth.
Amikacin was initially sold in 1976. It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.
Amikacin is most often used for treating severe, hospital-acquired infections with multidrug-resistant Gram-negative bacteria such as Pseudomonas aeruginosa, Acinetobacter, and Enterobacter. Serratia marcescens and Providencia stuartii are also included in the spectrum. Amikacin can also be used to treat non-tubercular mycobacterial infections and tuberculosis (if caused by sensitive strains) when first-line drugs fail to control the infection.
Amikacin may be combined with a beta-lactam antibiotic for empiric therapy for people with neutropenia and fever.
Liposomal amikacin for inhalation is currently in late stage clinical trials for the treatment of respiratory diseases, such as cystic fibrosis, Pseudomonas aeruginosa, non-tubercular mycobacterial infections and bronchiectasis.
Keywords:
Active Pharmaceutical Ingredients
Amines
Intermediates & Fine Chemicals
Oligosaccharides
Pharmaceuticals
Amikin
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