| Message: | 1) alcohol and other non steroidal anti-inflammatory drugs at the same time, will increase the gastrointestinal side effects, have caused dangerous ulcer.
(2) and aspirin and other salicylates with time, not increase the effect, and the bleeding and gastrointestinal side effects tend to a higher incidence of.
(3) and anti coagulation with medicine, increase the risk of bleeding.
(4) the product can improve the effect of anti diabetic drugs; reduce the drug of anti hypertension antihypertensive
Pharmacodynamics
Ketoprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. Ketoprofen has pharmacologic actions similar to those of other prototypical NSAIDs, which inhibit prostaglandin synthesis. Ketoprofen is used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and alleviate moderate pain.
Mechanism of action
The anti-inflammatory effects of ketoprofen are believed to be due to inhibition cylooxygenase-2 (COX-2), an enzyme involved in prostaglandin synthesis via the arachidonic acid pathway. This results in decreased levels of prostaglandins that mediate pain, fever and inflammation. Ketoprofen is a non-specific cyclooxygenase inhibitor and inhibition of COX-1 is thought to confer some of its side effects, such as GI upset and ulceration. Ketoprofen is thought to have anti-bradykinin activity, as well as lysosomal membrane-stabilizing action. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation.
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