| Message: | Once used as an antipyretic and analgesic, aminopyrine was prescribed in the treatment of the common cold, neuritis and rheumatism, and as a fever reducer. The drug works as a non-steroidal anti-inflammatory agent. Use of aminopyrine has been strongly discouraged because of its ability to cause leukopenia, also known as agranulocytosis or granulopenia. Leukopenia causes a dramatic decrease in white blood cells to occur, which increases the risk of serious infections.
The 13C-labeled aminopyrine is an ingredient in a non-invasive breath test used to measure cytochromes P-450 metabolic activity, which helps evaluate the liver's function. The drug is administered orally and the concentration of the drug in the breath's output is measured approximately two hours later. The amount of the drug in the breath helps to determine if the person suffers from liver disease or liver damage.
The drug has the ability to be almost totally absorbed by the body's gastrointestinal tract when administered orally, which makes it useful in liver function testing. Once absorbed, it is rapidly processed and metabolized through the liver. Measuring the saliva of the body approximately 18 hours after the medication has been administered helps to determine if the liver has successfully processed and metabolized the drug. This gives an idea of the liver's overall rate of function and its ability to successfully metabolize.
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