| Message: | The novel object recognition (NOR) is a widely used animal model for the investigation of memory alterations. Creative Biolabs uses this task to evaluate the effect of drug candidates on short-term memory, intermediate-term memory, and long-term memory, by assessment of the retention interval, that is, amount of time for which animals must retain memory of the sample objects placed during the recognition phase before the test phase, when one of the familiar objects is replaced by a novel one.
The NOR task is based on rodents' natural curiosity to explore their immediate environment. The test consists of a sample phase and a test phase. In the sample phase, the animal is given 10-15 min to freely explore two identical objects (object A), after which it will be returned to the home cage. After a delay, the animal is returned to the test arena where one of the sample objects has been replaced by a new one (object B). During this test phase, the time in contact with the objects is measured and a preference index is calculated. The assumption is that the animal would spend more time exploring the novel object than the familiar one, while equal time on the exploration of both objects suggests that the animal does not remember seeing the sample object. https://www.creative-biolabs.com/drug-discovery/therapeutics/novel-object-recognition-task.htm. |
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