| Message: | Cassette dosing is an efficient technique mainly applied in drug discovery efforts of pre-clinical studies, in order to obtain pharmacokinetic data from multiple candidate drugs in a single experiment. Thus, a similar amount of information obtained from 5-10 separate PK studies can be available from a single study. Cassette dosing studies can facilitate rapid evaluation of multiple compounds with a small number of animals. As a world leader in the industry of drug discovery, Creative Biolabs now provides cassette dosing studies for pharmacokinetic assays, in order to accelerate the speed of drug screening. Our scientists will spare no effort to assist you in formulating a most efficient and cost-effective proposal for your drug discovery projects.
Cassette dosing, alternatively called N-in-1 dosing, is an attractive procedure for higher-throughput screening in drug discovery to rapidly screen large numbers of candidate compounds for assessing their pharmacokinetic properties, while minimizing the number of animals. In a cassette dosing procure, multiple candidate compounds are administered simultaneously to a single animal. The plasma samples obtained from blood samples are analyzed through an assay method such as liquid chromatography coupled to tandem mass spectrometry, which enables simultaneously quantitative assays of several compounds in a single sample. Accordingly, the pharmacokinetics of multiple candidate compounds can be assessed rapidly in a relatively shortened assay time, and with a small number of experimental animals. On the other hand, co-administration of multiple compounds might cause pharmacokinetic drug-drug interactions. https://www.creative-biolabs.com/drug-discovery/therapeutics/cassette-dosing-studies.htm
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