| Message: | The blood/brain barrier (BBB) is formed by the brain endothelial cells and is identified as a structural and chemical barrier between the brain and systemic circulation. BBB studies are prerequisite for explaining preclinical efficacy and toxicology results. On the other hand, overcoming the obstacles of delivering therapeutic drugs to specific sites of the brain has become a main challenge of treating most brain diseases. With years of operational experience, Creative Biolabs now provides BBB study services using qualitative measurements of drug exposure, to evaluate your new therapeutic agents.
The blood/brain barrier (BBB) is highly selective semipermeable membrane barrier, which is defined as a physical and metabolic barrier that separates the circulating blood from the brain and extracellular fluid in the central nervous system (CNS). The blood/brain barrier is formed of brain capillary endothelium. It permits water, some gases, and lipid-soluble molecules to pass by passive diffusion, and also allows the selective transport of molecules such as glucose and amino acids that are essential to neural function. Moreover, it prevents the entrance of lipophilic potential neurotoxins by means of the P-glycoprotein-mediated active transport mechanism. Astrocytes have been supposed to be necessary to set up the blood-brain barrier. However, a few regions in the brains do not have a blood/brain barrier, such as the circumventricular organs. https://www.creative-biolabs.com/drug-discovery/therapeutics/blood-brain-barrier-bbb-studies.htm
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