| Message: | As an experienced Contract Research Organization (CRO), Creative Biolabs is committed to providing services of in vivo PK studies for the global pharmaceutical and biotech industries. Based on advanced technology and professional scientists, now we can provide high-quality mass balance study services employing a radioactive tracer to promote your drug discovery process. Our scientists have abundant experience working with plasma, urine, bile, tissue and cerebral spinal fluid (CSF), and will optimize the extraction conditions to provide a reproducible and robust method to help our clients’ drug development.
Mass balance studies are conducted to investigate the plasma pharmacokinetics and excretion of both the unchanged drug and the total radioactivity (drug and metabolites), and allows elucidation of the metabolic fate of a drug. It can provide fundamental information about the rates and routes of elimination of a new drug candidate. As a vital component of regulatory submissions, the main objective of mass balance study is the maximum recovery of the radioactive dose in urine and feces. Generally, the drug (both the labeled and the non-labeled portion of the dose) must be prepared, characterized and administered, and the biological samples must be collected and analyzed properly to obtain reliable and meaningful results.
https://www.creative-biolabs.com/drug-discovery/therapeutics/mass-balance-studies.htm. |
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