| Message: | Toxicokinetics (TK) is the analysis of the penetration into and fate within the body of a toxic substance as well as the possible emergence of metabolites. The goal of TK is to correlate findings of toxicity with a corresponding level of drug exposure. As an important part of drug development phase, TK studies are generally conducted according to several guidelines recommended by regulatory bodies (OECD). Furthermore, in addition to confirming exposure and establishing exposure parameters associated with the NOAEL, the data obtained from TK study is of great value in the selection of dose, dosing form, alternative dosing route, and evaluation of toxicological mechanism. https://www.creative-biolabs.com/drug-discovery/therapeutics/toxicokinetics-study.htm. |
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