| Message: | The primary concept of cancer immunotherapy is to enable the immune system to detect neoplastic growth and to either prevent carcinogenesis and/or reject transformed cells with a potential for malignant tumor growth. Tumor necrosis factor, also known as TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin, is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. The TNF gene is localized in the highly polymorphic region of human chromosome 6p21. It is expressed as a 26 kDa membrane-bound protein and is then cleaved by TNF-α converting enzyme (TACE) to release the soluble 17 kDa monomer that forms homotrimers in circulation. TNF-α is produced predominantly by activated macrophages in response to immunological challenges such as bacteria (lipopolysaccharides), viruses, parasites, mitogens and other cytokines, while it can also be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. https://www.creative-biolabs.com/drug-discovery/therapeutics/magic-humanized-tnf-immune-checkpoint-knock-in-mice.htm
|
my account
