| Message: | Immune checkpoint receptors are vital molecules for optimized adjusting immune responses. The tumor-permissive and immunosuppressive characteristics of tumor-associated macrophages (TAM) have aroused interest in therapeutically targeting these cells. Particularly, CSF1R-mediated signaling is critical for the differentiation and survival of the mononuclear phagocyte system and macrophages. Since CSF1R is also overexpressed in many cancers and on tumor-associated macrophages, CSF1R inhibitors have been widely studied for years as a potential treatment for cancer or inflammatory diseases. As a leading innovator in drug discovery, Creative Biolabs has developed a Magic™ “humanized” mouse model platform for therapeutic antibody development and evaluation. Especially, we now provide the humanized CSF1R knock-in mouse models and professional technical support for your novel antibody preclinical efficacy studies. https://www.creative-biolabs.com/drug-discovery/therapeutics/magic-humanized-csf1r-immune-checkpoint-knock-in-mice.htm
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