Message: | Immune checkpoints refer to a plethora of inhibitory pathways hardwired into the immune system that are critical for maintaining self-tolerance and modulating the duration and amplitude of physiological immune responses in peripheral tissues in order to minimize collateral tissue damage. Nowadays, among the most promising approaches to activating therapeutic antitumor immunity is the blockade of immune checkpoints. Creative Biolabs has successfully launched an optimized Magic™ “humanized” animal platform to offer specialty humanized ICOS immune checkpoint knock-in mice for our clients all over the world. https://www.creative-biolabs.com/drug-discovery/therapeutics/magic-humanized-icos-immune-checkpoint-knock-in-mice.htm. |