| Message: | Vasoactive intestinal polypeptide (VIP) has a wide physiological profile. In the periphery, it induces relaxation in smooth muscle; inhibits secretion in certain tissues, but stimulates secretion in others; and modulates activity of cells in the immune system. In the CNS, it has a range of both excitatory and inhibitory actions. VIP receptors are distributed widely in the periphery and occur throughout the gastrointestinal tract and genitourinary system, other smooth muscles and secretory glands. In the CNS, they are found abundantly in, e.g. the cortex, hippocampus, and thalamus. All VIP receptors activate adenylyl cyclase and induce cAMP production. https://www.creative-biolabs.com/drug-discovery/therapeutics/magic-vipr1-stable-cell-line.htm. |
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