| Message: | Arginine Vasopressin receptor 2 (AVPR2) belongs to the subfamily of G-protein coupled receptors. The binding of arginine vasopressin (AVP) to the V2 vasopressin receptor (V2R) stimulates a Gs-coupled protein that activates adenylyl cyclase (AC), in turn catalyzing the conversion of adenosine triphosphate (ATP) to 3',5'-cyclic AMP (cAMP) and pyrophosphate. The cAMP has been shown to activate protein kinase A (PKA). This pathway increases the exocytosis of aquaporin water channel-containing vesicles (AQMCV) and inhibits endocytosis of the vesicles, both resulting in increases in aquaporin 2 (AQ2) channel formation and apical membrane insertion. This allows an increase in the permeability of water from the collecting duct (CD).
https://www.creative-biolabs.com/drug-discovery/therapeutics/magic-avpr2-stable-cell-line.htm. |
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