Message: | Immunotherapy is a speedily expanding field of oncology aimed at targeting, not the tumor itself, but the immune system combating the cancerous lesion. And immune checkpoint inhibitors are now widely accepted as a key component of the therapeutic strategies in cancer. Several recent clinical studies show that the various immune checkpoint pathways play a critical role in the maintenance of tumor tolerance in humans since checkpoint blockade is associated with objective tumor responses and improved overall survival. With extensive experience in antibody-based drug discovery, Creative Biolabs has successfully established an efficient Magic™ “humanized” animal platform and can provide humanized PD-1/4-1BB dual immune checkpoint knock-in mice for our clients all over the world. https://www.creative-biolabs.com/drug-discovery/therapeutics/magic-humanized-pd-1-4-1bb-dual-immune-checkpoint-knock-in-mice.htm. |