| Message: | Raloxifene Hydrochloride CAS:82640-04-8
Product Name: Raloxifene Hydrochloride
Synonyms: Raloxifene HCL
CAS: 82640-04-8
MF: C28H28ClNO4S
MW: 510.04
mp: 250-253°C
storage temp: -20°C Freezer
solubility DMSO: 28 mg/mL, soluble
appearance: Light-Yellow Solid
Usage:
1.Amino acid, nutrient
2.Labeled Raloxifene, intended for use as an internal standard for the quantification of Raloxifene by GC- or LC-mass spectrometry.
3.A nonsteroidal, selective estrogen receptor modulator (SERM). Antiosteoporotic.
Application:
May prevent or treat corticosteroid-induced bone loss. American College of Rheumatology states that raloxifene can be offered to selected postmenopausal corticosteroid-treated women who refuse hormone replacement therapy or other antiresorptive agents or in whom such therapies are contraindicated.
Reduction in the incidence of invasive breast cancer inpostmenopausal women at high risk for developing the disease. Effect comparable to that of tamoxifen in reducing the risk of invasive breast cancer (STAR trial). No effect on the risk of lobular carcinoma in situ or ductal carcinoma in situ (STAR trial).
Effect on breast cancer incidence in women with BRCA1 or BRCA2 genetic mutations not established. Not indicated for the treatment of breast cancer or to reduce the risk of recurrence of breast cancer. 1 Not indicated for reduction in the risk of noninvasive breast cancer.
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