| Message: | Lidocaine CAS: 137-58-6
Product Name: Lidocaine
CAS: 137-58-6
MF: C14H22N2O
MW: 234.34
EINECS: 205-302-8
mp: 66-69°C
storage temp: Store at RT
solubility ethanol: 4 mg/mL
form: powder
Water Solubility: practically insoluble
Stability: Stable. Incompatible with strong oxidizing agents.
Usage: Lidocaine is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.
Application:
Lidocaine crosses the blood-brain and placental barriers, presumably by passive diffusion.
Lidocaine is metabolized rapidly by the liver, and metabolites and unchanged drug are excreted by the kidneys. Biotransformation includes oxidative N-dealkylation, ring hydroxylation, cleavage of the amide linkage, and conjugation. N-dealkylation, a major pathway of biotransformation, yields the metabolites monoethylglycinexylidide and glycinexylidide. The pharmacological/toxicological actions of these metabolites are similar to, but less potent than, those of Lidocaine. Approximately 90% of Lidocaine administered is excreted in the form of various metabolites, and less than 10% is excreted unchanged.
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