| Message: | Carbomer, also known as Carbopol, is a polymer polyacrylic acid cross-linked polymer, usually used as a thickener, gel, emulsifier in daily chemical products, and can also be used as a skeleton material for pharmaceutical excipients , It has the function of slow release agent or adhesion agent, dispersing agent, and has broad prospects in many fields.
Carbomer used as a sustained-release agent for tetanus toxoid
Bacterial exotoxin is treated with 0.3%~0.4% formaldehyde to remove its toxicity and can be made into toxoid. Tetanus (Clostridium tetani) toxoid is one of them. Its release study in carbomer (using flocculent precipitation method): Dissolve 25Lf/mL tetanus toxoid in phosphate buffer and distilled water, and then add equal amounts of 0.25%, 0.125%, and 0.625%. The concentration of carbopol is mixed thoroughly, and the carbopol is separated by the NaCl precipitation method, and then the supernatant and the carbopol precipitation are taken for flocculent reaction.
The results of the study found that the content of tetanus toxoid in the supernatant was very high, showing a typical flocculent precipitate, while the carbopol precipitate did not contain any tetanus toxoid, and the flocculent reaction was negative. This study initially established the biological detection method of this product in Carbopol gel and its dissolution conditions in Carbopol. It was determined that the Carbopol concentration for this release study should not be higher than 0.25%.
In addition, there are many other medicines that use carbomer as a skeleton material or carrier. The medicine is evenly dispersed in the carbomer gel. It will not directly dissolve in the solution (blood, body fluids), but will be released slowly for better performance. To medicinal effect. Desheng is a carbomer manufacturer, which can provide various types and requirements of carbomer raw materials. |
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