| Message: | https://www.sarmshgpharm.com/company-news/sarm-brief-introduction/
The reason we know that SARM has fewer side effects than anabolic steroids is that SARM selectively binds to androgen receptors in bone and muscle and does not affect other organs, so there are few side effects.
SARM AC 262 has an affinity of Ki=5nM for androgen receptors in skeletal muscle, whereas LGD4033 has an affinity of Ki=1nM for androgen receptors in skeletal muscle.
At the same time, SARM AC 262 had no significant affinity for any of the other receptors tested, and thus did not affect any organ at all except the androgen receptor in skeletal muscle.
In addition, SARM AC 262 is a partial agonist of the androgen receptor. Although the effect of partial agonists is not as dramatic as the effect of full agonists, this is not too much of a problem, as the SARM AC 262 is the mildest SARM, and bodybuilder can increase the dose as appropriate without producing a large effect. |
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