| Message: | https://www.sarmshgpharm.com/company-news/gw501516-vs-aicar/
Both Gw501516 and AICAR are not true SARM (androgen receptor modulators), but agonists of other receptors. When we talk about GW501516 vs AICAR, we need to know which class of agonists they belong to at first.
Gw501516 is a PPARδ agonist, also known as PPAR-Delta agonist, which is a completely synthetic design substance.
Aicar is an AMPK (AMP-activated protein kinase) activator, also known as PPAR-delta AMPK axis agonist, which is naturally produced in the body.
It can be seen from the above that PPAR-delta mainly regulates metabolism (especially glucose and lipid) and the maintenance of energy homeostasis, which can reverse the characteristic of human body's preferential consumption of muscle, burn fat as energy, reduce body fat, provide continuous power for Bodybuilder, and guarantee muscle quality in the case of energy shortage. Therefore, both GW501516 and AICAR can greatly improve Bodybuilder endurance.
AICAR acts as an AMPK agonist and promotes glucose uptake and translocation of sugar transporters in skeletal muscle; thus, even in sedentary mice, 4 weeks of AICAR treatment stimulated metabolic genes and increased running endurance by 44%. |
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