| Message: | Biological activity in vitro
SR9009（Stenabolic）for sale dose-dependently increased SR9009 and its analog SR9011 in HEK293 cells expressing the chimeric Gal4 DNA-binding domain: REV-ERB ligand-binding domain alpha or beta and a Gal4-responsive luciferase reporter gene in a dose-dependent manner increased REV-ERB-dependent repressor activity. Furthermore, SR9009 was found to inhibit BMAL1 messenger RNA expression in HepG2 cells in a REV-ERB-α/β-dependent manner
Biological activity in vivo
The researchers found in mice that SR9009 caused a reduction in fat mass and blood lipids. In vivo, SR9009 inhibited the growth of malignant gliomas and improved their survival in mice without causing significant toxicity. SR9009 penetrates the blood-brain barrier and inhibits tumor growth in a xenograft model using patient-derived malignant glioma explants. Significantly improved survival in two different models of malignant glioma.
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