| Message: | The use of chloramphenicol should be limited to serious infections where positive bacteriological evidence and clinical judgement indicates that chloramohenicol is an appropriate antibiotic.
Warnings:
The risk of aplastic anaemia does not restrict the use of chloramphenicol in situations in which it is necessary;however,it emphasizes that the drug should never be employed in diseases readily,safely and effectively treatable with other antimicrobial agents or in undefined cases.
The use of chloramphenicol during pregnancy is best avoided.
Repeated courses and prolonged treatment should be avoided.
Concomitant administration of chloramphenicol with other drugs liable to depress bone-marrow function should be avoided.
Chloramphenicol enhances the effects of coumarin anticoagulants,some hypoglycaemic agents (chlorpropamide and tolbutamide) and phenytoin.
Dosage and Administration:
Adults:-500mg every 6 hours or 50mg/kg body mass daily in divided doses every 6 hours.
The dose of chloramphenicol should be reduced in the presence of hepatic disease or in patients with renal insufficiency.
Children:-25 to 50 every 6 hours or 50mg/kg body mass daily,given in divided doses at intervals of 6 hours.
Storage instructions: Store below 25 degrees and protect from light. Keep out of reach of children.
Validity: Three Years
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