| Message: | Pharmacokinetics:
Rifampicin is readily absorbed from the gastro intestinal tract and peak plasma concentrations of about 7 to 10 ug per ml have been reported 2 to 4 hours after a dose of 600 mg but there may be considerable interindvidual variation.Approximately 80% wouldbound to plasma proteins.It is widely distributed in body tissues and fluids and diffures into the cerebrospinal fluid when the meninges are inflamed an can crosses the placenta and distrbute in breast milk.Half-lives for rifampicin have been reported to range initially from 2 to 5 hours.It is rapidly metabolised in the liver and excreted in the bile.Meanwhile up to 30% may be excreted in the urine.
Indications:
Rifampicin in used ,notably is combination with isoniazid and pyrazinamide,as a component of multidrug regimens for the treatmrnt of tuberculosis,and with dapsone and clofazimine in the treatment of leprosy.Other uses include treatment of staphylococcal infections,brucellosis,and legionnaires disease and the prophylaxis of haemophilus and meningococcal meningitis.
Adverse Effects:
Rifampicin is usually well tolerated.The main adverse effects are a flu-like syndrome and a cutaneous syndrome.Hepatotoxicity also occurs.Gastor-intestinal adverse effects include nausea,vomiting,anorexia,diarrhoea,and epigastric distress.
Precautions:
Liver function should be checked before and during treatment.Blood counts should be monitored during prolonged treatment and in patients with hepatic disorders.
Administration&dosage:
The usual adults dose of rifampicin is 600 mg daily by mouth.preferably on an empty stomach orally administration on an ermpty stomach in single daily doses of 10 mg per kg body-weight(maximum 600 mg)to children and adults is recommended.The maximum dose is considered to be 900 mg.
Storage:
Store in airtight containers protect from light in cool place.
Validity: Three Years
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