| Message: | Pharmacological Action:
Miconazole nitrate is a synthetic 1-phenethylimidazole derivative. It is a broad spectrum anti-fungal agent. In vitro, low concentrations of miconazole nitrate are fungistatic against all Phycomycetes, Ascomycetes and Adelomycetes tested (e.g. Saprolegnia, Candida, Cryptococcus, Aspergillus, Dermatophytes, Phialophora, Sporotrichum), and fungicidal against Trichophyton mentagrophytes, Trichophyton rubrum, Epidermophyton floccosum. Trichophyton interdigitale and Microsporum canis.
Miconazole nitrate also possesses some anti-bacterial activity against Gram-positive organisms.
Indication:
Dermatomycoses, e.g,:
-Tinea pedis (Athlete’s foot)
-Tinea corporis (Tinea circinata)
-Tinea manuum
Tinea cruris due to:
-Trichophyton mentagrophytes
-Trichophyton rubrum
-Microsporum audouinii
-Epidermophyton floccosum
Candidial infections:
Infections of the skin (e.g. intertrigo)
Perianal infections
Stomatitis angularis (cheilitis, perleche)
Balanoposthitis
Contra-indications:
Miconazole nitrate is contra-indicated in those patients who have shown hypersensitivity to miconazole.
Dosage and Directions for use:
For external use only.
Miconazole nitrate should be applied to the lesions twice daily and thoroughly rubbed into the skin. When all lesions have disappeared (usually after 2 to 5 weeks) treatment should be continued for a further 10 to 14 days to prevent relapse.
Storage Instructions:
Store in a cool and dry place between 15-30℃ .protect from light.
KEEP OUT OF REACH OF CHILDREN.
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